Approximately 20% of patients with acute Q fever will develop chronic fatigue, referred to as Q fever fatigue syndrome (QFS). The objective of this randomized controlled clinical trial was to assess the efficacy of either long-term treatment with doxycycline or cognitive-behavioral therapy (CBT) in reducing fatigue severity in patients with QFS. Adult patients were included who met the QFS criteria according to the Dutch guideline: a new onset of severe fatigue lasting ≥6 months with significant disabilities, related to an acute Q fever infection, without other somatic or psychiatric comorbidity explaining the fatigue. Using block randomization, patients were randomized between oral study medication and CBT (2:1) for 24 weeks. Second, a double-blind randomization between doxycycline (200 mg/day, once daily) and placebo was performed in the medication group. Primary outcome was fatigue severity at end of treatment (EOT; week 26), assessed with the Checklist Individual Strength subscale Fatigue Severity. Of 155 patients randomized, 154 were included in the intention-to-treat analysis (doxycycline, 52; placebo, 52; CBT, 50). Doxycycline is a antibiotic that has a variety of side effects, which includes acid reflux and the possibility for an allergic reaction. It can also cause some other very serious side effects, such as permanent yellowing of teeth and, in infants or children, a sudden stoppage of bone growth. As with any antibiotic, the risks of side effects must be balanced with the advantages of using that particular antibiotic. Doxycycline is an antibiotic that is related to tetracycline. It can be used to treat a variety of infections, including bacterial and certain kinds of parasitic infections. It is often used to treat acne and diseases of the urinary tract and reproductive system. It can also be used prophylactically to prevent malaria.
Doxycycline oral tablet can cause side effects. Some are. The more common side effects of doxycycline can include. This drug does not cause drowsiness. Doxycycline is an antibiotic in the tetracycline family that works by inhibiting bacterial growth in the body. Doctors prescribe doxycycline to fight bacterial.