They belong to different classes and have different mechanisms of action. While they both have broad spectrum activity against various gram-positive and gram-negative bacteria, some resistance has developed to both drugs. The choice of which antibiotic to use will be made by the treating doctor according to the illness, organism causing it, and susceptibility of the organism. While both antibiotics fight bacterial infections, the way in which they do that differs. Doxycycline belongs to the class of drugs called tetracyclines, which work by interfering with protein synthesis of the bacteria, thus not allowing the organism to replicate. It is referred to as a bacteriostatic agent, which means that it stops the bacteria from multiplying. The body's immune system kills off the bacteria already there. The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. Doxycycline in these solutions is stable under fluorescent light for 48 hours, but must be protected from direct sunlight during storage and infusion. Susceptibility Plate Testing: If the Kirby-Bauer method of disc susceptibility is used, a 30 mcg doxycycline disc should give a zone of at least 16 mm when tested against a doxycycline-susceptible strain. PLEASE READ THE Reconstituted solutions (1 to 0.1 mg/m L) may be stored up to 72 hours prior to start of infusion if refrigerated and protected from sunlight and artificial light. Solutions must be used within these time periods or discarded. Doxycycline is primarily bacteriostatic and thought to exert its antimicrobial effect by the inhibition of protein synthesis. A tetracycline disc may be used to determine microbial susceptibility. Doxycycline is stable for 48 hours in solution when diluted with Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP, to concentrations between 1 mg/m L and 0.1 mg/m L and stored at 25°C. Doxycycline is active against a wide range of gram-positive and gram-negative organisms. is 4 to 12.5 mcg/m L and resistant (not likely to respond to therapy) if the M. If the Kirby-Bauer method of disc susceptibility is used, a 30 mcg tetracycline disc should give a zone of at least 19 mm when tested against a tetracycline-susceptible bacterial strain. The drugs in the tetracycline class have closely similar antimicrobial spectra, and cross resistance among them is common. Microorganisms may be considered intermediate (harboring partial resistance) if the M. Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. Microorganisms may be considered susceptible to doxycycline (likely to respond to doxycycline therapy) if the minimum inhibitory concentration (M. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form. Following a 100 mg single dose administered in a concentration of 0.4 mg/m L in a one-hour infusion, normal adult volunteers average a peak of 2.5 mcg/m L, while 200 mg of a concentration of 0.4 mg/m L administered over two hours average a peak of 3.6 mcg/m L.
Doxycycline for dogs is an antibiotic from the tetracyclines family. The original members of this broad-spectrum antibiotic group include tetracycline and oxytetracycline. Doxycycline, however, is a more modern drug with fewer side effects and a higher safety margin. These features tend to make doxycycline the medication of choice when a tetracycline antibiotic is indicated. This means that it stops the bacteria from reproducing, rather than kills bacteria outright. This may seem an academic point, but it has important implications for treatment. Prior treatment with a bacteriostat antibiotic such as doxycycline, can reduce the effectiveness of other antibiotics should they be needed. Therefore, your veterinarian will want to be certain that doxycycline is the right medication for the job and the bacterial infection will respond. In addition to the general indications for all members of the tetracycline antibiotics group, doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease, Moraxella catarrhalis, Brucella melitensis, Chlamydia pneumoniae, and Mycoplasma pneumoniae are generally susceptible to doxycycline, while some Haemophilus spp., Mycoplasma hominis, and Pseudomonas aeruginosa have developed resistance to varying degrees. Some Gram-positive bacteria have developed resistance to doxycycline. Up to 44% of Streptococcus pyogenes and up to 74% of S. faecalis specimens have developed resistance to the tetracycline group of antibiotics. When bacteriologic testing indicates appropriate susceptibility to the drug, doxycycline may be used to treat these infections caused by Gram-positive bacteria: The World Health Organization Guidelines states that the combination of doxycycline with either artesunate or quinine may be used for the treatment of uncomplicated malaria due to Plasmodium falciparum or following intravenous treatment of severe malaria. Doxycycline kills the symbiotic Wolbachia bacteria in the reproductive tracts of parasitic filarial nematodes, making the nematodes sterile, and thus reducing transmission of diseases such as onchocerciasis and elephantiasis. Doxycycline has been used successfully to treat sexually transmitted, respiratory, and ophthalmic infections.
OVID MEDLINE, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL) and relevant references and conference proceedings using the Web of Science and Scopus databases were searched for randomized controlled trials comparing bactericidal with bacteriostatic antibiotics for treatment of severe infections. Main outcome measures were clinical cure rates and overall mortality. Abstracts of studies selected in the database search were screened by one reviewer; full-text screening and data extraction were performed by three independent reviewers. = 0.28) were different between patients treated with bactericidal drugs and those treated with bacteriostatic drugs. Subgroup analyses showed a benefit for clinical cure rates associated with linezolid and increased mortality associated with tigecycline. In meta-regression, clinical cure rates remained higher in patients treated with linezolid (The categorization of antibiotics into bacteriostatic and bactericidal is unlikely to be relevant in clinical practice if used for abdominal infections, skin and soft tissue infections and pneumonia. Because we were not able to include studies on meningitis, endocarditis or neutropenia, no conclusion regarding these diseases can be drawn. The bacteriostatic antibiotics include the macrolides, tetracyclines, aminoglycosides and other agents like chloramphemnicol and clindamycin. They inhibit bacterial protein synthesis by acting on bacterial ribosomal units. In addition to the bacteriostatic activity, each drug class has other characteristic mechanisms:. Antiacids containing magnesium or aluminum may lower peak serum levels of azithromycin, and food will decrease absorption of the oral dose (also available IV). Hepatic impairment may interfere with azithromycin elimination. Erythromycin is also indicated to treat otitis media in combination with sulfisoxazole. It may cause cardiac arrhythmias and QT prolongation, and blocks the metabolism of carbamazepine, digoxin, theophilline and warfarin.
Vibramycin doxycycline hyclate for injection Intravenous is an antibacterial drug synthetically. Doxycycline has bacteriostatic activity against a broad range of. Learn tetracyclines bacteriostatic with free interactive flashcards. Choose from 53 different sets of tetracyclines bacteriostatic flashcards on Quizlet.