We used three different studies involving patients undergoing detoxification to evaluate the worth of propranolol hydrochloride in withdrawal of opiates. If propranolol acts as a narcotic antagonist, the patient's condition should become worse and require increased methadone hydrochloride; if it were to afford symptomatic relief by blocking autonomic responses, methadone requirements might be decreased. None of the studies indicated that propranolol hydrochloride in doses of 160 mg/day or less aggravated withdrawal symptoms. Patients treated with the drug consistently required a somewhat smaller methadone dose for detoxification. Patients who responded favorably had mild withdrawal symptoms. The small benefit from the drug hardly merits its consideration as an adjunct to the treatment of withdrawal from opiates. Three groups of hypertensive patients were studied after they had received one of the three pharmacologically different beta blockers for at least 1 month: pindolol, 10 mg twice a day (n = 7), propranolol median dose, 80 mg three times a day (n = 9), or metoprolol, 150 mg (twice a day (n = 8). After abrupt withdrawal of drug and replacement with placebo, we mwasured the following on day 0 and approximately every 2 days up to 3 weeks; beta-adrenergic sensitivity (BAS) by the chronotropic dose of isoproterenol to increase heart rate by 25 bpm (CD values of 618 μg for pindolol, 57 μg for propranolol, and 10 μg for metoprolol as compared to 2.8, 2.4, and 3.0 μg, respectively, at days 14 to 21, which were considered the ultimate baseline. After pindolol on day 0, the CD decreased significantly two- to fivefold below baseline from days 4 to 14 (↑BAS) and after metoprolol two- to threefold below baseline from days 2 to 8. After pindolol, heart rate and blood pressure gradually returned to, but not above, ultimate baseline. In contrast, during the period of ↑BAS there was a significant overshoot of heart rate in eight of eight patients after metoprolol (day 0 = 61, peak = 88, baseline = 74) but not after propranolol, while a significant overshoot of blood pressure occurred in six of nine patients after propranolol () but not after metoprolol. Withdrawal symptoms of headache, palpitations, and tremor occurred in one of seven patients after pindolol, six of nine after propranolol, and three of eight after metoprolol. The degree and duration of beta blockade appeared related to drug potency.
High blood pressure (hypertension) is a common problem across the globe and can have severe consequences on health. High blood pressure is treated by many drugs, and beta blocker is one of them, which helps to reduce the blood pressure. As these medicines are taken regularly and for a long period, it is important to know the symptoms and effects of beta blocker withdrawal. As high blood pressure can affect blood vessels and damage major organs, beta blockers are used to effectively control blood pressure and prevent complications. Beta blockers are also extensively prescribed to patients suffering from high level of anxiety and stress. Along with high blood pressure, beta blockers are useful in treating ailments like abnormal heart rate, angina pain and when there is an increased risk of heart failure. The use of beta blockers may be reduced once the heart begins to perform normally. This is not a list of all drugs or health problems that interact with propranolol injection. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take propranolol injection with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. However, many people have no side effects or only have minor side effects.
Four of the five patients developed one or more of the above-mentioned symptoms within 2-6 days after withdrawal of propranolol. 4. A mean relative increase. I was wondering if Propranolol would help me with the withdrawal symptoms to I can make it through work days. I just want this feeling to go away, I am currently.