The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. The NICE British National Formulary (BNF) and British National Formulary for Children (BNFc) sites are only available to users in the UK, Crown Dependencies and British Overseas Territories. If you believe you are seeing this page in error please contact us.
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. The dose of Viagra should be gauged by a healthcare provider, and we cannot stress this enough. Self-administration is highly unadvisable, or you are asking for trouble. However, for general educational purposes we’ve prepped a hands-on guide on how to know you made-to-measure Viagra dose. Who is it for: Generic Viagra 25 mg is the minimal dose of sildenafil citrate, and as such it is the very first step you take in your therapy. Whether or not this will be escalated as you hitch closer to your tailored posology scheme is a question of many factors and combinations thereof. The important adage is that you start off by taking those baby steps and see what your body thinks of the new drug. The trick: What you should know about the minimal dose is that you are not likely to really feel the efficacy of the drug at its fullest with the first few pills; not because the dose is ineffective, but rather because of sildenafil nature. You might say that sildenafil is the opposite of addictive – it builds up and improves responsiveness of your body over time, so that diminishing dose is not such a rare scene in many patients.
Pretreatment with erythromycin 500 mg twice daily for 5 days, a specific CYP3A4 inhibitor, increased the AUC of a single 100-mg dose of sildenafil by 182%. It is recommended that a lower initial sildenafil dose 25 mg be considered in patients with ED receiving potent CYP3A4 inhibitors such as erythromycin. Sildenafil a review of its use in erectile dysfunction. Langtry HD1, Markham A. Author information 1Adis International Limited, Mairangi Bay, Auckland, New Zealand. Sildenafil is an oral therapy for erectile dysfunction of a broad range of causes.